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Defective platelet aggregation to the calcium ionophore A23187 in a patient with a lifelong bleeding disorder.
  1. S J Machin,
  2. J P Keenan,
  3. B A McVerry


    A patient with a lifelong bleeding disorder is presented with a prolonged bleeding time and abnormal aggregation and secretion responses to arachidonic acid, thromboxane A2, PAF-acether and the divalent calcium ionophore A23187. Platelet alpha and dense granule contents and morphology appear normal. The proposed defect is due to an abnormality of a platelet intracellular calcium dependent process.

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