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Antibody synthesis within the central nervous system: comparisons of CSF IgG indices and electrophoresis
  1. EJ Thompson*,
  2. PG Riches,
  3. J Kohn
  1. * Institute of Neurology, The National Hospital, Queen Square, London WC1
  2. Protein Reference Unit, Westminster Hospital, London SW1
  3. St Luke's Hospital, Guildford, Surrey.


    Various laboratories have reported differing success rates in their ability to detect intrathecal synthesis of antibody when comparing the index of [Formula: see text] with electrophoretic analysis. We selected 44 patients in the borderline area of minimal and/or equivocal abnormality by IgG index. Electrophoretic analysis (on polyacrylamide gels for oligoclonal gamma globulin pattern) of parallel specimens was performed at the same time. The number of samples giving a normal index but showing oligoclonal bands varied between 34% and 43% depending on the cut-off point. The views about normal barrier functions underlying such indices are discussed with particular reference to the pathophysiology of the blood-CSF barrier.

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      BMJ Publishing Group Ltd and Association of Clinical Pathologists