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Plasma spermidine concentrations as early indication of response to therapy in human myeloma.
  1. O A Van Dobbenburgh,
  2. B Houwen,
  3. H Jurjens,
  4. J Marrink,
  5. M R Halie,
  6. H O Nieweg


    Eighteen patients with melphalan refractory myeloma were treated with vindesine and prednisone. Plasma spermidine concentrations were measured by radioimmunoassay before and after a single vindesine injection. Seven patients showed a significant rise of plasma spermidine after vindesine and five of these showed a clinical response on further evaluation. Of the 11 patients who did not show raised spermidine concentrations, 10 did not respond to the therapy. The correlation between clinical response/rise of spermidine and between non-response/no rise of spermidine was statistically significant (p less than 0.05). Pretreatment spermidine concentrations did not distinguish those who responded to treatment nor did they differ in patients and controls.

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