Article Text

Download PDFPDF

Pathophysiology of human lipoprotein receptors: clinical consequences of a cellular defect.
  1. J Shepherd,
  2. C J Packard


    The function of the low density lipoprotein receptor has been reviewed at the cell level and in man. Its key role in cholesterol metabolism is unquestioned and it is central to the actions of a number of important hypocholesterolaemic agents. Clearly it must be involved in atherogenesis since its dysfunction leads to premature and severe atherosclerosis in both animals and man. The tools are now available to address this question and answers should be forthcoming in the near future.

    Statistics from

    Request Permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.