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The platelet defect in acute myeloid leukaemia.
  1. B E Woodcock,
  2. P C Cooper,
  3. P R Brown,
  4. C Pickering,
  5. D A Winfield,
  6. F E Preston


    In a study of platelets from 13 patients with acute myeloid leukaemia abnormal aggregation and release reactions were found. A previously unrecognised quantitative defect of thromboxane B2 production may, at least in part, explain these findings. In contrast to a previous report, we were unable to show a convincing storage pool defect in these platelets. The platelet membrane glycoproteins were largely normal.

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