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Killing of Escherichia coli by human polymorphonuclear leucocytes in the presence of Bacteroides fragilis.
  1. W A Vel,
  2. F Namavar,
  3. A M Verweij-van Vught,
  4. A N Pubben,
  5. D M MacLaren


    The inhibitory effect of Bacteroides fragilis on the in vitro killing of Escherichia coli by polymorphonuclear leucocytes was studied with two pairs of E coli and B fragilis isolated from human wound infections. Both B fragilis strains behaved similarly: they inhibited the killing of one E coli strain, while the killing of the other E coli strain was not affected. The different behaviour of the two E coli strains depended on their need for fresh serum in the killing by the polymorphonuclear leucocytes. The inhibitory effect of the B fragilis strains could be completely accounted for by their effect on complement.

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