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Distribution of vitamin B12 R-binder in carcinomas of the digestive tract.
  1. H Kudo,
  2. G Ohshio,
  3. K Ogawa,
  4. Y C Kim,
  5. Y Wakatsuki,
  6. Y Nakashima,
  7. H Yamabe,
  8. M Inada
  1. Department of Geriatric Medicine, Faculty of Medicine, Kyoto University, Japan.


    To evaluate whether the increase in serum transcobalamin I, seen in patients with carcinoma, is caused by synthesis of R-binder to tumour cells, the distribution of vitamin B12 R-binder in 125 malignant growths of the digestive tract was studied. Positive staining for R-binder with immunoperoxidase was observed in 85 (70%) carcinomas. Positive staining for R-binder was observed in all four cholangiocarcinomas studied, but was absent in nine hepatocellular carcinomas. These findings suggest that determination of R-binder in liver tumours may be of some value in differentiating hepatocellular carcinomas and cholangiocarcinoma, and that synthesis of R-binder by tumour cells causes an increase in serum transcobalamin I.

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