Article Text

Download PDFPDF

Dicentric chromosome in the bone marrow of a child with megakaryoblastic leukaemia and Down's syndrome.
  1. A O Wilkie,
  2. C Kitchen,
  3. A Oakhill,
  4. R T Howell,
  5. P J Berry
  1. Department of Paediatric Oncology, Bristol Children's Hospital.


    A two year old girl with Down's syndrome (constitutional karyotype: 47 + 21), presenting with pancytopenia, developed acute megakaryoblastic leukaemia (AMKL). Her bone marrow contained an abnormal clone with a novel dicentric chromosome derived from chromosomes 5 and 7 (karyotype 46, XX, -5, -7, +dic (5;7) (p 13; p 11.2), +21. This case provides further evidence for a connection between chromosome 21 and this unusual form of childhood leukaemia, and raises questions about the loss of short arm material from chromosomes 5 and 7 compared with the more usual monosomy or long arm loss.

    Statistics from

    Request Permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.