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Rapid diagnosis of whooping cough using monoclonal antibody.
  1. P C Boreland,
  2. S H Gillespie,
  3. L A Ashworth
  1. Department of Medical Microbiology, Waveney Hospital, Ballymena, Ireland.


    A counterimmunoelectrophoresis (CIE) method for antigen detection using monoclonal antibody was assessed for its ability to aid in the rapid diagnosis of Bordetella pertussis in 59 patients. A positive diagnosis from a combination of results from tests of serum and urine was obtained in 51 (87%) of cases. For sera, CIE had a sensitivity of 85% and a specificity of 94%; for urine samples the sensitivity was 81% and a specificity of 100%. Antigen detection by CIE is simple to perform and yields results on the same day, thus allowing treatment to begin at an early stage.

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