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Definitive identification of human T cells in formalin fixed paraffin wax embedded tissue.
  1. N D Francis,
  2. D M Clark,
  3. A W Boylston
  1. Pathology Department, St Mary's Hospital Medical School, London.


    The use of a new monoclonal antibody, BF1, which reacts in routinely fixed tissues, directed against the beta chain of the T cell antigen receptor was assessed to determine its reactivity in a variety of normal tissues as well as in a number of B and T cell tumours and other lymphoid disorders. It reacted with all five of the unequivocal T cell tumours tested. BF1 will have widespread use in the assessment of lymphoid tissues in patients with the acquired immune deficiency syndrome (AIDS) and the differential diagnosis of tumours.

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