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Association between CAM 5.2 and anti-CD1a reactivity in lymph nodes and gastrointestinal tract epithelium.
  1. A S Jack,
  2. I Grigor,
  3. C J O'Brien,
  4. W McMeekin,
  5. F Lewis,
  6. A M McNicol
  1. Department of Pathology, University of Leeds.


    Immunocytochemical studies, using the antibodies CAM 5.2 and NA1/34 (CD1a), were performed on normal lymphoid tissue and malignant lymphomas. A population of dendritic cells in the paracortex of lymph nodes and in T cell lymphomas reacted with both antibodies. Colocalisation with antibodies was also found in gastrointestinal epithelium. Immune blotting shows that the likely basis of this reactivity is a 12 kilodalton peptide which is recognised by both antibodies. This is almost certainly the beta t peptide which has been described as the light chain of CD1a.

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