Article Text

Download PDFPDF
Observer variability in histopathological reporting of transitional cell carcinoma and epithelial dysplasia in bladders.
  1. A J Robertson,
  2. J S Beck,
  3. R A Burnett,
  4. S R Howatson,
  5. F D Lee,
  6. A M Lessells,
  7. K M McLaren,
  8. S M Moss,
  9. J G Simpson,
  10. G D Smith
  1. Department of Pathology, Ninewells Hospital and Medical School, Dundee, Scotland.


    Sections from 90 urinary bladder biopsy specimens were examined by 11 consultant histopathologists with varying experience to determine the appropriateness of existing pathology terminology. Analysis with kappa statistics showed fair to good agreement in the grading and staging of transitional cell carcinoma. There was also reasonable agreement in the diagnosis of high grade dysplasia in random biopsy specimens from the urothelium adjacent to the neoplasm, but very poor agreement for lesser degrees of dysplasia. It is concluded that the present classification of bladder carcinomata is reliable and that pathologists can determine stage with a high degree of reproducibility and grade with a fair degree of reproducibility.

    Statistics from

    Request Permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.