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Disseminated pneumocystis carinii infection in AIDS.
  1. R J Coker,
  2. D Clark,
  3. E L Claydon,
  4. M Gompels,
  5. J G Ainsworth,
  6. S B Lucas,
  7. R Miller,
  8. R D Goldin,
  9. A J Pinching,
  10. J R Harris
  1. Department of Genitourinary Medicine, St. Mary's Hospital and Medical School, London.


    Eight patients with AIDS and Pneumocystis carinii infection were studied. Protean manifestations were a feature not untypical of disseminated pneumocystosis. Aerosolised pentamidine as prophylaxis against P carinii pneumonia was ineffective at suppressing dissemination. The knowledge that extrapulmonary infection can occur has implications for the detection and treatment of, and prophylaxis against, P carinii infection. The survival of patients with disseminated pneumocystosis is particularly poor, and may be due to a lack of clinical awareness and consequent delay in diagnosis.

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