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Bleeding diathesis coincident with chronic myelomonocytic leukaemia.
  1. S E Heard,
  2. P Revell,
  3. L J Holland,
  4. A D Hurdle,
  5. G F Savidge
  1. Supra-Regional Haemophilia Centre, St Thomas's Hospital, London.


    Two important haematological problems were found in an otherwise healthy 78 year old man: chronic myelomonocytic leukaemia; and a complex, acquired, hyperfibrinolytic bleeding disorder characterized by prolonged coagulation times, deficiency of coagulation factors V, X, and XI, anti-thrombin III and proteins C and S, with high concentrations of circulating tissue plasminogen activator, and low concentrations of plasminogen activator inhibitor. There may be a causal relation between the two conditions, with the peripheral blood monocytes mediating the hyperfibrinolytic process by the abnormal production of tissue plasminogen activator, though no previous description of a similar association has been reported.

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