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Histometric studies on cellular infiltrates of tuberculin tests in patients with sarcoidosis.
  1. J G Lowe,
  2. J H Gibbs,
  3. R C Potts,
  4. J L Stanford,
  5. J Swanson Beck
  1. Department of Dermatology, Ninewells Hospital and Medical School, Dundee.


    The density and microanatomical location of CD4 and CD8 lymphocytes and of monocytes/macrophages at the site of a tuberculin test were measured in 13 patients with sarcoidosis, and the results were compared with those seen in a group of healthy controls. The cellular infiltrate was significantly reduced in the sarcoid subjects compared with the controls for all cell phenotypes studied; the ratio of CD4 positive:CD8 positive lymphocytes was significantly increased in the sarcoid group. Clinically negative reactions showed substantial numbers of infiltrating mononuclear cells, although not as great as in clinically apparent reactions. A clinically negative tuberculin reaction does not necessarily imply anergy to the test substance and should not be termed "negative".

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