Article Text

Download PDFPDF
Multinucleated stromal giant cells in adolescent gynaecomastia.
  1. A P Campbell
  1. Nuffield Department of Pathology and Bacteriology, John Radcliffe Hospital, Headington, Oxford.


    Bizzare multinucleated stromal giant cells were observed in a case of adolescent gynaecomastia. Similar cells have been described in the female breast in both benign and malignant conditions where they are thought to originate either from reactive stromal cells or from the mononuclear phagocyte system, respectively. Immunohistochemistry and electron microscopy in this case support the idea that they originate from stromal fibroblasts. Their occurrence in gynaecomastia is further evidence that these changes in stromal cells may be due to hormonal influences.

    Statistics from

    Request Permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.