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Electron microscopic and immunohistochemical findings in a case of olfactory neuroblastoma.
  1. Z M Du,
  2. Y S Li,
  3. B F Wang
  1. Department of Pathology, Fourth Military Medical University, Xi'an Shaanxi, People's Republic of China.


    A case of olfactory neuroblastoma is reported. Light microscopic examination showed various arrangements of poorly differentiated tumour cells forming either uniform sheets or convoluted cords of multiple cell layers orientated toward a richly vascular stroma. Electron microscopic examination showed the presence of abundant cytoplasmic filaments and processes, and dense core endocrine vesicles ranging from 100-160 nm in diameter in both the perinuclear region and tumour cell processes. Immunohistochemical staining was positive in most of the tumour cells for neuron specific enolase, and in a few cells for S-100 protein, vimentin, and serotonin, but staining for desmin and keratin produced no reaction.

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