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Transforming growth factor beta 1 as a prognostic factor in pulmonary adenocarcinoma.
  1. I Takanami,
  2. T Imamura,
  3. T Hashizume,
  4. K Kikuchi,
  5. Y Yamamoto,
  6. S Kodaira
  1. Department of Pathology, Teikyo University School of Medicine, Tokyo, Japan.


    AIMS--To evaluate the efficacy of transforming growth factor beta (TGF-beta) for the prognosis of pulmonary adenocarcinoma. METHODS--TGF-beta was detected immunohistochemically using the avidin-biotin-peroxidase complex technique in resected pulmonary adenocarcinomas from 88 patients. RESULTS--Of the 88 patients, 39 were TGF-beta negative and 45 TGF-beta positive. The five year survival rate was 56% for the TGF-beta negative and 16% for the TGF-beta positive group. CONCLUSIONS--TGF-beta can be used as a prognostic factor in pulmonary adenocarcinoma.

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