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Polycythaemia rubra vera transforming to acute lymphoblastic leukaemia with a common immunophenotype.
  1. J R Neilson,
  2. W N Patton,
  3. M D Williams,
  4. E E Mayne,
  5. B J Boughton
  1. Department of Haematology, Queen Elizabeth Hospital, Birmingham.


    Lymphoblastic transformation of polycythaemia rubra vera is an extremely rare phenomenon. A case of a 76 year old man with polycythaemia rubra vera who developed acute lymphoblastic leukaemia (ALL) 16 years after his initial diagnosis is reported. Membrane markers showed a CD10 positive (common ALL) immunophenotype. To our knowledge this association has not been previously recorded. The rare occurrence of ALL in polycythaemia rubra vera may indicate that in a minority of patients clonal expansion of an abnormal pluripotent haemopoietic stem cell is responsible for the polycythaemia rubra vera disease phenotype.

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