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Malignant melanoma showing smooth muscle differentiation.
  1. S S Banerjee,
  2. P W Bishop,
  3. C M Nicholson,
  4. B P Eyden
  1. Department of Pathology, Christie Hospital, Manchester.


    A unique case of a metastatic non-desmoplastic sarcomatoid malignant melanoma in an axillary lymph node showing smooth muscle differentiation in a 54 year old woman is described. The tumour cells exhibited alpha-smooth muscle actin, HHF-35 and desmin positivity but were negative for S100 protein and HMB-45. Ultrastructural examination revealed smooth muscle phenotype and there was no evidence of myofibroblastic differentiation, a feature described previously in desmoplastic melanomas.

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