You are here

Article Text

Article menu
Download PDFPDF
Research Article
Immunohistological analysis of tumour growth factor beta 1 expression in normal and inflamed salivary glands.
  1. Y Kizu,
  2. H Sakurai,
  3. S Katagiri,
  4. N Shinozaki,
  5. M Ono,
  6. K Tsubota,
  7. J Saito
  1. Department of Oral Medicine, Tokyo Dental College, Chiba, Japan.

    Abstract

    AIM: To determine whether transforming growth factor-beta 1 (TGF-beta 1) has a pathogenetic role in disease of the salivary glands. METHODS: An indirect immunohistochemical technique was used to analyse TGF-beta 1 expression in six specimens of normal salivary gland and 23 surgical specimens. RESULTS: TGF-beta 1 was strongly expressed in the ductal epithelial cells of normal salivary gland tissues (six of six cases) and in inflammatory conditions (eight of 11 cases). In contrast, TGF-beta 1 was not detectable in ductal epithelial cells expressing HLA-DR around infiltrating CD4+ CD45RO+ activated T cells, in the salivary gland tissue of patients with Sjögren's syndrome. CONCLUSION: Because TGF-beta 1 has an essential role in the mucosal immunity of salivary glands, abnormal expression of this cytokine must be regarded as a candidate in the pathogenesis of Sjögren's syndrome.

    https://doi.org/10.1136/jcp.49.9.728

    Statistics from Altmetric.com

      Request Permissions

      If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.