Article Text

Download PDFPDF

Inflammatory pseudotumour and Rosai-Dorfman disease of soft tissue: a histological continuum?
  1. D Govender,
  2. R Chetty
  1. Department of Anatomical Pathology, Faculty of Medicine, University of Natal, Durban, South Africa.


    A lesion of the chest wall in a 34 year old woman, which had a combination of histological and immunophenotypic features of inflammatory pseudotumor and Rosai-Dorfman disease of soft tissue, is described. There was considerable overlap in the pathogenesis, histology and immunophenotype of these two lesions. The similarities between these two lesions suggest that there is a temporal sequence and a histological continuum with early histiocyte-rich and late fibroblast- and myofibroblast-rich lesions. Alternatively, the morphological and immunophenotypic features could be because of aberrant cytokine expression in an inflammatory pseudotumour, resulting in transformation of histiocytes to resemble those seen in Rosai-Dorfman disease.

    Statistics from

    Supplementary materials

    Related Data

    Request Permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

    Linked Articles