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Human herpesvirus 6 latently infects mononuclear cells but not liver tissue.
  1. T Yoshikawa,
  2. K Suzuki,
  3. M Ihira,
  4. H Furukawa,
  5. S Suga,
  6. T Iwasaki,
  7. T Kurata,
  8. K Asonuma,
  9. K Tanaka,
  10. Y Asano
  1. Department of Paediatrics, Fujita Health University School of Medicine, Aichi, Japan.


    AIM: To investigate whether human herpesvirus 6 (HHV-6) can cause latent infection of liver tissue. METHODS: Peripheral blood and liver tissue were collected from 25 living related liver transplant recipients at the time of transplantation. An avidin-biotin complex peroxidase method was used to identify HHV-6 antigen in the liver tissue. A nested polymerase chain reaction (PCR) was used to detect HHV-6 DNA in the liver tissue and mononuclear cells. Variant of HHV-6 was determined by the presence of the Hind III site in a second PCR product. RESULTS: Immunohistochemical analysis for HHV-6 antigen was negative in all the liver specimens. HHV-6 DNA was not detected in liver tissue. Virus DNA was detected in peripheral blood mononuclear cells in nine of 25 recipients. All nine HHV-6 identified in the mononuclear cells were variant B. CONCLUSIONS: HHV-6 variant B latently infects mononuclear cells but not liver tissue.

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