You are here

Article Text

Article menu
Download PDFPDF
Possible involvement of IL-12 expression by Epstein-Barr virus in Sjögren syndrome.
  1. M Horiuchi,
  2. S Yamano,
  3. H Inoue,
  4. J Ishii,
  5. Y Nagata,
  6. H Adachi,
  7. M Ono,
  8. J N Renard,
  9. F Mizuno,
  10. Y Hayashi,
  11. I Saito
  1. Department of Microbiology, Tokyo Medical University, Japan.

    Abstract

    AIM: To determine the correlation between interleukin 12 (IL-12) expression and Epstein-Barr virus (EBV) in Sjögren syndrome. METHODS: Indirect immunohistochemical technique, enzyme linked immunosorbent assay (ELISA), and immunoblot analysis were used to investigate IL-12 expression by EBV activation, using 13 surgical specimens and four B cell lines. RESULTS: Marked expression of IL-12 was found in the epithelial cells and the infiltrating B cells of salivary gland tissues from patients with Sjögren syndrome (six of 10 cases), but not in those from normal individuals (none of three cases). A striking topographic correlation between IL-12 and EBV was found. In addition, levels of IL-12 production by B cell lines were clearly enhanced by EBV activation in vitro. CONCLUSIONS: IL-12 expression closely reflects the intracellular event of EBV activation in Sjögren syndrome, and may contribute to the T helper cell type 1 (Th1) cytokine overexpression seen in this disease.

    https://doi.org/10.1136/jcp.52.11.833

    Statistics from Altmetric.com

      Request Permissions

      If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.