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CD10 positive thyroid marginal zone non-Hodgkin lymphoma.
  1. E K Millar,
  2. S Waldron,
  3. A Spencer,
  4. S Braye
  1. Department of Anatomical Pathology, John Hunter Hospital, Hunter Region Mail Centre, Lambton, Australia.


    A 72 year old woman presented with swelling of the right lobe of her thyroid gland. Fine needle aspiration and flow cytometry showed a clonal population of B cells expressing CD10 and a diagnosis of follicle centre cell lymphoma was made. Subsequent excision of the thyroid showed the typical histological features of a marginal zone non-Hodgkin lymphoma. Polymerase chain reaction showed no evidence of t (14;18). Immunohistochemistry confirmed CD10 positivity and LN1 (CDw75) expression. This is only the second report of aberrant expression of CD 10 by a marginal zone lymphoma.

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