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Telomerase expression in intracranial tumours: prognostic potential for malignant gliomas and meningiomas.
  1. M L Falchetti,
  2. R Pallini,
  3. L M Larocca,
  4. R Verna,
  5. E D'Ambrosio
  1. Istituto di Medicina Sperimentale, CNR, Rome, Italy.


    AIM: To evaluate the diagnostic value of telomerase expression in intracranial tumours. METHODS: 98 surgical specimens from different neoplasms were analysed by the telomeric repeat amplification protocol (TRAP) and the presence of telomerase compared with the histological diagnosis and the proliferation index. RESULTS: A high degree of positivity for telomerase activity was found in glioblastomas and atypical/anaplastic meningiomas. Telomerase activity was poorly detected in anaplastic astrocytomas. CONCLUSIONS: The TRAP assay seems to be a valuable index for identifying meningeal tumours with aggressive behaviour.

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