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Proton Pump Inhibitors.
  1. E J Kuipers

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    Olbe L, ed. (£92.00.) Birkhauser, 1999. ISBN 3 7643 5897 1.

    In the past decade, proton pump inhibitors have dramatically changed the treatment of acid related disorders. They profoundly suppress gastric acid, without the development of tolerance or side effects, and are very commonly used. As such, this book edited by Dr Olbe is of interest to clinicians, physiologists, and pharmacists. The book is written by experts in the field and largely consists of two sections on pharmacology and clinical effects. The first section covers among others the mechanism of action and the consequences of acid inhibition in animals and humans. The second section focuses on the use of proton pump inhibitors for ulcer disease, Zollinger-Ellison syndrome, and gastro-oesophageal reflux disease. Thus, the book deals with many topics. Unfortunately, the subject index is limited, which hampers its use as a quick reference. Furthermore, several currently relevant issues are not, or only briefly, discussed. These include the new formulation of omeprazole in a multiple pellet solution, the use of intravenous formulations for upper gastrointestinal bleeding, the possibility of nocturnal acid breakthrough and fundic gland polyp formation during treatment, as well as that of rebound hypersecretion after the withdrawal of treatment. Finally, the topic of Helicobacter pylori and atrophic gastritis is discussed repeatedly, but only some of the arguments mentioned in the international literature are brought forward. Therefore, a second edition of the book would benefit from such updating for clinicians who are interested in the newest aspects of proton pump inhibitor treatment.

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