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Haemophagocytic syndrome and histiocytic necrotising lymphadenitis (Kikuchi's disease)
  1. U Mahadeva1,
  2. T Allport2,
  3. B Bain3,
  4. W K Chan1
  1. 1Department of Histopathology, St Mary's Hospital, Praed Street, London W2 1NY, UK
  2. 2Department of Paediatrics, St Mary's Hospital
  3. 3Department of Haematology, St Mary's Hospital
  1. Dr Mahadeva, Department of Histopathology, Royal Marsden NHS Trust, Fulham Road, London SW3 6JJ, UK


A young boy presented with a rash, fever, and cervical lymphadenopathy, originally thought to be caused by tuberculosis. A lymph node biopsy showed the features of Kikuchi's disease, with necrosis and histiocytic infiltration without neutrophils. No evidence of tuberculosis was found on staining, culture, or the polymerase chain reaction. Bone marrow biopsy revealed prominent haemophagocytosis, and a diagnosis of haemophagocytic syndrome was reached. The aetiology of haemophagocytic syndrome, and its association with Kikuchi's lymphadenitis, is discussed.

  • Kikuchi's disease
  • histiocytic necrotising lymphadenitis
  • histiocytic haemophagocytosis
  • haemophagocytic syndrome

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