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Raised plasma parathyroid hormone related peptide in gastric adenocarcinoma
  1. Georg Engelich1,
  2. Niall Swan1,
  3. Kevan L Hartshorn1
  1. 1Boston University School of Medicine and Boston Medical Center, Departments of Medicine and Pathology, 80 East Concord Street, Boston,MA 02118, USA

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    We report a case of humoral hypercalcemia associated with a rapidly growing gastric carcinoma. To our knowledge, this is the first such case of gastric carcinoma reported with raised plasma parathyroid hormone related peptide (PTHrP) and absent bone metastases.

    A 69 year old woman presented with fatigue and intermittent sharp epigastric pain for one week. Upper gastrointestinal radiographs and endoscopy demonstrated a necrotic, friable mass in the mid stomach. Biopsy of the mass and a surrounding satellite polypoid lesion showed poorly differentiated adenocarcinoma and gastric adenoma with high grade dysplasia, respectively (fig 1). Four weeks after the first symptoms had arisen the liver edge was …

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