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  • Primitive small round cell tumour of the adrenal gland presenting with fever of unknown origin and t(12;22)(q13;q12) cytogenetic finding

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Primitive small round cell tumour of the adrenal gland presenting with fever of unknown origin and t(12;22)(q13;q12) cytogenetic finding
  1. K Y Lam1,
  2. C Y Lo2,
  3. T W H Shek1,
  4. E S K Ma1,
  5. W Y Au3,
  6. G C F Chan4
  1. 1Department of Pathology, University of Hong Kong, Queen Mary Hospital, Pokfulam Road, Hong Kong, China
  2. 2Department of Surgery, University of Hong Kong
  3. 3Department of Medicine, University of Hong Kong
  4. 4Department of Paediatrics, University of Hong Kong
  1. Dr Lam, Pathology Division, School of Medicine, James Cook University Douglas Campus, Townsville, Queensland, QLD 4811, Australia akylam{at}hotmail.com

Abstract

This report describes a left adrenal tumour in a 16 year old Chinese girl who presented with fever of unknown origin. The histological and ultrastructural features of the adrenal tumour were those of a primitive small round cell tumour with neuroendocrine differentiation. Cytogenetic analysis of cultured tumour cells showed a reciprocal translocation t(12;22)(q13;q12). This is the first example of such a tumour being reported in the adrenal gland. The adrenal tumour was also the cause of the fever, which subsided after the removal of the tumour.

  • adrenal
  • cytogenetic
  • primitive tumour
  • pyrexia of unknown origin

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