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High prevalence of serum markers of coeliac disease in patients with chronic fatigue syndrome
  1. A Skowera1,
  2. M Peakman1,
  3. A Cleare2,
  4. E Davies2,
  5. A Deale2,
  6. S Wessely2
  1. 1Department of Immunology, Guy's King's and St Thomas's School of Medicine, Denmark Hill Campus, London SE5 9RS, UK
  2. 2Department of Psychological Medicine, Guy's King's and at Thomas's School of Medicine

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    There has been recent interest in the possibility that undiagnosed coeliac disease (CD) might be the cause of diverse clinical symptoms, most particularly “tired all the time”.1 A recent study reported a prevalence of three in 100 cases in a primary care environment in which samples were taken from patients with a range of symptoms and signs.2 The second most frequent symptom reported by the endomysial antibody (EMA) positive patients was “being tired all the time”. We decided to examine the prevalence of EMA in patients attending our tertiary referral centre with the diagnosis of chronic fatigue syndrome (CFS).

    We tested serum from 100 consecutive patients (47 men, 53 women; median age, 40 years; range, 18–57) referred to …

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