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An unusually aggressive case of endometriosis showing p53 expression
  1. S M Ismail1,
  2. S Vandeginste2,
  3. R W Shaw2
  1. 1Department of Pathology, University of Wales College of Medicine, Heath Park, Cardiff CF4 4XN, UK
  2. 2Department of Obstetrics and Gynaecology, University of Wales College of Medicine
  1. Dr Ismail ismailsm{at}


A 43 year old woman who underwent a hysterectomy and bilateral salpingo-oophorectomy for secondary dysmenorrhoea was found to have bilateral ovarian endometriosis. During the following four years she developed a series of tumour-like vaginal masses, which were locally excised, a pelvic mass causing acute large bowel obstruction, which necessitated an emergency Hartmann's procedure, and a further pelvic mass causing hydronephrosis with a non-functioning kidney. Pathological examination of all the resected specimens showed endometriosis with abundant stromal and glandular elements. Immunoreactivity for p53 protein was detected within endometriotic foci from the initial oophorectomy as well as the latest resection specimens. Immunostaining for p53 may help identify potentially aggressive cases of endometriosis for proactive treatment.

  • endometriosis
  • p53
  • immunocytochemistry

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