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Case report
Scedosporium apiospermum in chronic granulomatous disease treated with an HLA matched bone marrow transplant
  1. M M Gompels1,
  2. C A Bethune2,
  3. G Jackson2,
  4. G P Spickett2
  1. 1Department of Immunology, Southmead Hospital, Bristol, BS10 5NB, UK
  2. 2Department of Immunology, Royal Victoria Infirmary, Newcastle upon Tyne NE1 4LP, UK
  1. Correspondence to:
 Dr M M Gompels, Department of Immunology, Southmead Hospital, Bristol BS10 5NB, UK;
 boblock75{at}hotmail.com

Abstract

A patient with chronic granulomatous disease who was being treated with steroids was diagnosed with a soft tissue Scedosporium apiospermum infection. Despite extensive treatment with antifungals progression to involve solid tissue (bone) occurred. Treatment required an HLA matched bone marrow transplant, which led to complete clearance of the fungal infection, although the patient subsequently died.

  • Scedosporium apiospermum
  • chronic granulomatous disease
  • infection
  • bone marrow transplantation
  • CGD, chronic granulomatous disease
  • CRP, C reactive protein
  • IFN-γ, interferon γ
  • HLA, human leucocyte antigen
  • PHLS, Public Health Laboratory Service

https://doi.org/10.1136/jcp.55.10.784

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