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Thrombin switches on RANTES synthesis in RA

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Researchers have shown for the first time that development of rheumatoid arthritis (RA) entails stimulation of synthesis of a chemokine by thrombin. They further suggest that the expression of the RANTES chemokine’s mRNA occurs by a protease activated receptor-1 (PAR-1) pathway.

PAR-1 and PAR-3 were expressed in isolated …

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