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Progression on metastatic neuroendocrine carcinoma from a recurrent prolactinoma: a case report


A 54 year old man was referred to the department of neurosurgery for frontal headache and vomiting. The patient was known in the department because of previous multiple surgery for a locally invasive pituitary prolactinoma (eight years, three years, and one year previously). The neurological examination revealed a frontal mass, which adhered to the dura, suggesting a meningioma. One year later, a left temporal metastasis was removed. Three months later, the patient died, with spinal metastases, of massive lung embolism. Histology revealed a progression of adenohypophyseal prolactinoma on neuroendocrine carcinoma, with an increase in proliferating indexes and modification of hormone production. This study documents a 10 year history of a rare prolactin producing pituitary carcinoma, which metastasised via liquoral flow.

  • pituitary carcinoma
  • prolactinoma
  • metastasis, proliferating index
  • electron microscopy
  • ACTH, adrenocorticotrophin
  • CT, computed tomography
  • GH, growth hormone
  • MRI, magnetic resonance imaging
  • PCNA, proliferating cell nuclear antigen
  • PRL, prolactin

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