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Localisation of C reactive protein in infarcted tissue sites of multiple organs during sepsis
  1. A Baidoshvili1,
  2. R Nijmeijer1,
  3. W K Lagrand2,
  4. C E Hack3,
  5. H W M Niessen1
  1. 1Department of Pathology, Vrije Universiteit Medical Center ICAR-VU, 1081 HV Amsterdam, The Netherlands
  2. 2Department of Cardiology, Vrije Universiteit Medical Center
  3. 3CLB, Sanguin Blood Supply Foundation, Plesmanlaan 125, 1066 CX Amsterdam, The Netherlands
  1. Correspondence to:
 Dr HWM Niessen, Vrije Universiteit Medical Center, Department of Pathology, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands;


This report hypothesises an active role for the acute phase protein, C reactive protein (CRP), in local inflammatory reactions. This was studied in infarction sites from liver and kidney in a patient who died as a result of multiple complications after cholecystectomy. In this patient, a general acute phase protein reaction was induced, with an increase in plasma CRP. In infarction sites of kidney and liver, colocalisation of CRP and activated complement were found, whereas non-infarct sites were negative for CRP and complement. These results suggest that CRP directly participates in local inflammatory processes, possibly via complement activation, after binding of a suitable ligand.

  • C reactive protein
  • infarcted tissue
  • sepsis
  • complement
  • CRP, C reactive protein

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