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  • Renal oncocytoma with a novel chromosomal rearrangement, der(13)t(13;16)(p11;p11), associated with a renal cell carcinoma

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Renal oncocytoma with a novel chromosomal rearrangement, der(13)t(13;16)(p11;p11), associated with a renal cell carcinoma
  1. X Leroy1,
  2. E Leteurtre1,
  3. P H Mahe1,
  4. B Gosselin1,
  5. B Delobel2,
  6. M F Croquette2
  1. 1Service d'Anatomie et de Cytologie Pathologiques, Faculté de Médecine, Pôle Recherche, Rue Polonovski, CHRU, 59045 Lille Cedex, France; x-leroy@chru-lille.fr
  2. 2Laboratory of Cytogenetics, Saint-Antoine Hospital, Lille, France

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      Oncocytoma is a benign epithelial tumour that makes up approximately 5–7% of primary renal neoplasms.1 This tumour can be bilateral or multifocal and in 10% of cases there is an association between oncocytoma and renal cell carcinoma.2 We report the case of a renal oncocytoma associated with a necrotic and cystic clear cell carcinoma. A cytogenetic study of the oncocytoma showed a new chromosomal rearrangement, namely: der(13)t(13;16)(p11;p11).

      A 75 year old man with an unremarkable medical history presented with abdominal pain. Echotomography and an abdominal computed tomography scan showed two solid tumours in the right kidney. The first tumour measured 4.5 cm, was located at the lower pole of the kidney, and appeared to be necrotic. The second tumour measured 3 cm, was homogeneous, and was located in the periphery of the first tumour. A radical right nephrectomy was performed.

      Gross examination showed two tumours at the lower pole of the kidney. The first tumour measured 4.5 cm in its largest diameter. It was partially cystic and largely necrotic. The second tumour measured 3 cm. It was solid, homogeneous, and had a brown …

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