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Keratan sulphate MAB 5-D-4 and βig-h3 protein accumulation in corneas

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    Build up of keratan sulphate and βig-h3 protein in the cornea causes opacity in Maroteaux-Lamy syndrome (MLS) type B, as shown for the first time by researchers in Cardiff, UK. MLS is one of the mucopolysaccharide diseases. A deficiency in a lysosomal enzyme causes build up of glycoaminoglycans (mucopolysaccharide) within the cornea, causing it to become opaque. In MLS …

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