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Extranodal marginal zone B cell lymphoma of MALT type involving the mucosa of both the urinary bladder and stomach


Primary lymphoma of the urinary bladder is a very rare tumour. A bladder tumour was found in a 57 year old man with obstructive dysuria. It was found by histological and immunohistohistochemical investigation to be an extranodal marginal zone B cell lymphoma. Lymphoepithelial lesions were absent, but were found in a clinically silent gastric lymphoma discovered four weeks later during staging investigations; this gastric lymphoma was negative for Helicobacter pylori by breath test and molecular biological analysis. Sequencing of the clonal immunoglobulin heavy chain gene in both tumours indicated the same precursor cell, of follicular or post follicular origin. In synopsis, the data suggested that this was a case of primary lymphoma of the bladder with involvement of the stomach. The application of a chromosome 3 specific α satellite probe revealed trisomy 3. A tumour with these characteristics arising as a lymphoma of the bladder with a metachronous involvement of the gastric mucosa has not been described previously.

  • extranodal marginal zone B cell lymphoma
  • urinary bladder
  • mucosa associated lymphoid tissue
  • polymerase chain reaction
  • FISH, fluorescence in situ hybridisation
  • IgH, immunoglobulin heavy chain
  • MALT, mucosa associated lymphoid tissue
  • MZBL, marginal zone B cell lymphoma
  • NHL, non-Hodgkin's lymphoma
  • PCR, polymerase chain reaction

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