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Re: Whither smooth muscle antibodies in the third millennium?
  1. S J Katona,
  2. P C Cooper,
  3. M E Cramp,
  4. E R Kaminski
  1. Department of Immunology, Level 7, Derriford Hospital, Plymouth PL6 8DH, UK;

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    We read with great interest the article by Silvestrini et al.1 In November 1999, patient 1 (table 1) presented with malaise, arthralgia, thrombocytopaenia, low complement values, abnormal liver function tests, a strong homogeneous antinuclear antibody (ANA) result, and smooth muscle antibodies. We demonstrated that this patient's smooth muscle antibodies were specific for actin using Hep2 cells, a result that is suggestive of type 1 autoimmune hepatitis, and which was later confirmed by liver biopsy. Since then, we have tried to determine the target specificity of smooth muscle antibodies in …

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