Article Text

Download PDFPDF
Changes produced in the urothelium by traditional and newer therapeutic procedures for bladder cancer


A handful of traditional and newer therapeutic procedures, such as chemotherapy, immunotherapy, radiotherapy, photodynamic and laser treatment, and gene therapy, are used to treat epithelial malignancies of bladder origin. These treatment modalities, used either intravesically or systemically, produce morphological changes in the urothelial mucosa that can be mistaken for carcinoma. The pathologist must be able to separate toxic and drug related alterations from tumour related changes. The clinical history is usually invaluable in this assessment.

  • bladder cancer
  • chemotherapy
  • immunotherapy
  • radiotherapy
  • gene therapy
  • BCG, Bacillus Calmette-Guérin
  • CIS, carcinoma in situ
  • IFN, interferon
  • IL, interleukin
  • TURB, transurethral resection of the bladder

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.