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H pylori may trigger cancers by switching off a tumour suppressor

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Silencing of a cell surface adhesin in gastric mucosa in Helicobacter pylori infection may lead to gastric cancer, a molecular study has suggested. Methylation of the E-cadherin gene promoter—which inactivates its normal tumour suppressor function—was evident in gastric mucosa and significantly associated with H pylori infection in patients with …

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