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Increase in serum 1,25-dihydroxyvitamin D and hypercalcaemia in a patient with inflammatory myofibroblastic tumour
  1. A Ogose1,
  2. H Kawashima1,
  3. O Morita1,
  4. T Hotta1,
  5. H Umezu2,
  6. N Endo1
  1. 1Division of Orthopedic Surgery, Department of Regenerative and Transplant Medicine, Course for Biological Functions and Medical Control, Graduate School of Medical and Dental Sciences, Niigata University, Niigata 951–8510, Japan
  2. 2Section of Pathology Niigata University Hospital, Niigata 951-8510, Japan
  1. Correspondence to:
 Dr A Ogose, Department of Orthopedic Surgery, Niigata University, School of Medicine, Niigata 951–8510, Japan; 


Hypercalcaemia complicates the clinical course of a substantial number of patients with advanced cancer. This report describes a patient with an inflammatory myofibroblastic tumour in soft tissue who developed an inflammatory reaction, hypercalcaemia, and a high serum concentration of 1,25 dihydroxyvitamin D. Serum concentrations of 25-hydroxyvitamin D, parathyroid hormone, and parathyroid hormone related protein were normal. Histological examination of the tumour revealed fibrosarcoma with abundant macrophage infiltration. mRNA for 25-hydroxyvitamin D-1α-hydroxylase was identified in the tumoral tissue. In view of this case, inflammatory myofibroblastic tumour should be added to the list of diseases that are responsible for vitamin D mediated hypercalcaemia.

  • inflammatory fibrosarcoma
  • hypercalcaemia
  • 25-hydroxyvitamin D-1α-hydroxylase
  • vitamin D
  • 1,25(OH)2 D, 1,25 dihydroxyvitamin D
  • PCR, polymerase chain reaction
  • PTHrP, parathyroid hormone related protein

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