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Clear cell carcinoma of the breast with solid papillary pattern: a case report with immunohistochemical profile
  1. Y Gürbüz,
  2. S K Özkara
  1. Department of Pathology, Kocaeli University, Medical School, 41900, Derince, Kocaeli, Turkey
  1. Correspondence to:
 Dr S K Özkara, Mustafa Pasa Mahallesi, Bagdat Caddesi, 0712. Sokak, No: 19/6, 41400, Gebze, Kocaeli, Turkey; 


Glycogen rich clear cell carcinoma of the breast is a rare neoplasm with different morphological characteristics to ordinary breast carcinomas. However, it has some common features with clear cell carcinomas of other organs. This report describes a case of clear cell carcinoma of the breast with a solid papillary pattern centrally localised in the left breast of a 45 year old woman. Antibodies directed against cytokeratin 7 (CK7), CK10, CK14, CK17, CK18, CK19, CK20, CK5/6/18, CK8/18, high molecular weight cytokeratin AE3, high molecular weight cytokeratin 34βE12, the oestrogen receptor, the progesterone receptor, chromogranin, S-100 protein, smooth muscle actin, vimentin, and carcinoembryogenic antigen were applied to analyse the immunophenotypical profile of this rare neoplasm.

  • glycogen rich clear cell carcinoma
  • breast
  • immunohistochemistry
  • CCC, clear cell carcinoma
  • CEA, carcinoembryogenic antigen
  • CK, cytokeratin
  • CR, chromogranin
  • ER, oestrogen receptor
  • HMWCK, high molecular weight cytokeratin
  • PAS, periodic acid Schiff
  • PR, progesterone receptor
  • RCC, renal cell carcinoma
  • SMA, smooth muscle actin

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