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Expression of smooth muscle markers in so called malignant fibrous histiocytomas
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  • Published on:
    Author's reply to Zardawi

    Dear Editor

    We appreciated the comments of Dr Zardawi [1] and agree that actin is a ubiquitous cytoskeletal protein of microfilaments and demonstrable in a variety of cells and tumor types. As we described, all leiomyosarcomas are smooth muscle actin (SMA)-positive, and desmin, muscle specific actin (MSA) and h-caldesmon are positive in a great majority of these tumors. However, none of these is absolutely specifi...

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    Conflict of Interest:
    None declared.
  • Published on:
    Re: Expression of smooth muscle markers in so called malignant fibrous histiocytoma

    Dear Editor

    I read with interest the article on the expression of smooth muscle markers in so called malignant fibrous histiocytomas by Hasegawa et al. in the Journal.[1]

    While I agree with Hasegawa and colleagues that pleomorphic malignant fibrous histiocytoma can be regarded as an undifferentiated sarcoma, I feel Hasegawa et al are placing too much reliance on so called smooth muscle markers. Most...

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    Conflict of Interest:
    None declared.