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Diffuse and intestinal type gastric carcinomas differ in their expression of apoptosis related proteins
  1. C J van der Woude1,
  2. J H Kleibeuker1,
  3. A T G M Tiebosch2,
  4. M Homan1,
  5. A Beuving1,
  6. P L M Jansen1,
  7. H Moshage1
  1. 1Department of Gastroenterology, University Hospital Groningen, The Netherlands
  2. 2Department of Pathology, University Hospital Groningen, The Netherlands
  1. Correspondence to:
 Dr C J van der Woude, Department of Gastroenterology, Molewaterplein 40, 3015 GD Rotterdam, The Netherlands;
 woudevannee{at}planet.nl

Abstract

Background: Gastric carcinomas can be divided into intestinal and diffuse types, with the last type having a worse prognosis.

Aims: To investigate whether specific patterns in the expression of apoptosis related proteins correlate with carcinoma type and/or prognosis

Methods: The expression of Fas, Bcl-2, Bax, Bcl-xl, cyclooxygenase-2 (COX-2), and inducible nitric oxide synthase (iNOS) was studied immunohistochemically and the extent of apoptosis and proliferation was investigated in 11 cases of intestinal type and in eight cases of diffuse type carcinoma.

Results: Fas was expressed in all intestinal type and in one diffuse type carcinoma. Bcl-xl was expressed in 10 of 11 intestinal type and in one of eight diffuse type carcinomas. Bcl-2 was expressed in lamina propria immune cells. iNOS was expressed in six of 11 intestinal type and in four of eight diffuse type carcinomas, and COX-2 was expressed in eight of 11 intestinal type and in six of eight diffuse type carcinomas.

Conclusion: Fas and Bcl-xl expression can differentiate between intestinal type and diffuse type gastric carcinomas. No differences in apoptosis and proliferation between intestinal type and diffuse type gastric carcinomas were observed.

  • intestinal-type gastric carcinoma
  • diffuse-type gastric carcinoma
  • apoptosis, inducible nitric oxide synthase
  • COX-2
  • Bax
  • Fas
  • Bcl-2
  • Bcl-xl
  • active caspase-3
  • COX-2, cyclooxygenase 2
  • FasL, Fas ligand
  • iNOS, inducible nitric oxide synthase
  • NF-κB, factor nuclear factor κB
  • NO, nitric oxide

https://doi.org/10.1136/jcp.56.9.699

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