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Leiomyoma of the bladder in a patient with von Recklinghausen’s neurofibromatosis
  1. T L Däuth1,
  2. M Conradie2,
  3. R Chetty1
  1. 1Department of Pathology, Nelson R Mandela School of Medicine, University of Natal, Congella 4013, Durban, South Africa
  2. 2Department of Urology, Nelson R Mandela School of Medicine
  1. Correspondence to:
 Dr T L Däuth, Department of Pathology, Nelson R Mandela School of Medicine, Private Bag 7, Congella 4013, Durban, South Africa;traceydau{at}ialch.co.za

Abstract

Leiomyomas are an uncommon manifestation of neurofibromatosis type 1 (NF-1) and occur most often in the gastrointestinal tract. Here, they have a proclivity for the proximal small bowel and tend to be multiple. Urinary tract involvement by NF-1 is usually in the form of neurofibromas, and leiomyomas are exceptionally rare. This report describes a case of solitary leiomyoma occurring in a 49 year old woman with NF-1. The patient had symptoms related to a lower urinary tract infection and on examination was found to have a distended bladder. Imaging of the bladder showed a mass involving the posterior wall, neck, and trigone causing bilateral hydronephrosis. The mass was excised with part of the bladder. Microscopic examination revealed typical features of a leiomyoma and there was strong immunoreactivity for desmin and smooth muscle actin. Leiomyoma must be considered in the differential diagnosis of spindle cell neoplasms in patients with NF-1.

  • leiomyoma
  • neurofibromatosis type 1
  • urinary tract

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