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Correspondence
Concurrent vitreous disease may produce abnormal vitreous humour biochemistry and toxicology
  1. M A Parsons1,
  2. R D Start2,
  3. A R W Forrest3
  1. 1Ophthalmic Sciences Unit, Royal Hallamshire Hospital (Floor O), Glossop Road, Sheffield S10 2JF, UK; a.parsons@sheffield.ac.uk
  2. 2Department of Pathology, Chesterfield Royal Hospital, Calow, Chesterfield S44 5BL, UK
  3. 3Medico-Legal Centre, University of Sheffield, Watery Street, Sheffield S3 7ES, UK

    https://doi.org/10.1136/jcp.56.9.720-a

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      We read with interest the conclusions of Jones and Holgrem1 that caution is needed when the results of postmortem vitreous humour ethanol concentrations are used to estimate the concentration of femoral venous blood, via the calculation of ethanol distribution ratios (vitreous humour/femoral venous blood).

      The most common reason for vitreous removal at necropsy is for biochemical or toxicological analysis to assist in determining the cause and time of death.2,3 The possibility that the sampled vitreous humour may have intrinsic abnormalities related to eye disease does not appear to be considered in the extensive literature reporting biochemical and toxicological findings in the vitreous humour. This possibility, however remote, is not discussed by Jones and Holgrem in their paper.

      Ophthalmic pathological examination indicates that the vitreous humour is involved in a wide range of eye …

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