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Influence of recipient and donor IL-1α, IL-4, and TNFα genotypes on the incidence of acute renal allograft rejection
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  1. H Lee1,
  2. B Clark1,
  3. H C Gooi1,
  4. J Stoves2,
  5. C G Newstead2
  1. 1Department of Transplantation Immunology, St James’s University Hospital, Leeds, LS9 7TF, UK
  2. 2Renal Transplant Unit, St James’s University Hospital
  1. Correspondence to:
 Dr H Lee
 Transplantation Laboratory, Manchester Royal Infirmary, Oxford Road, Manchester, M13 9WL, UK; helena.leecmmc.nhs.uk

Abstract

Aims: To determine whether polymorphisms of the genes encoding donor or recipient interleukin 1α (IL-1α), tumour necrosis factor α (TNFα), or IL-4 have any impact on the incidence of acute rejection after renal transplantation.

Methods: All donors and recipients were genotyped for three polymorphisms in the three cytokine genes: IL1A −889, TNFA −308, and IL4 –590.

Results: Statistical analysis of the data obtained revealed no association between the cytokine gene polymorphisms tested and the incidence of post-transplant acute rejection. After stratification for human leucocyte antigen (HLA) matching, it was found that kidneys from donors positive for the TNFA-A allele had a significantly increased incidence of acute rejection in HLA-DR mismatched transplants.

Conclusions: This finding argues for prospective TNFA genotyping of renal donors, with avoidance of allocation of kidneys from donors positive for the TNFA-A allele to HLA-DR mismatched recipients.

  • acute renal allograft rejection
  • donor cytokine genotype
  • recipient cytokine genotype
  • IL, interleukin
  • HLA, human leucocyte antigen
  • MHC, major histocompatibility complex
  • PCR, polymerase chain reaction
  • TNF, tumour necrosis factor
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