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Isolated bone marrow mycosis in a patient presenting with consumptive symptoms
  1. A Zimpfer1,
  2. P Piehler2,
  3. G Kofler3,
  4. S Dirnhofer4,
  5. A Tzankov5
  1. 1Institute of Pathology, University of Innsbruck, 6020 Innsbruck, Austria
  2. 2Department of Internal Medicine, Helios Hospital, A-6370 Kitzbühel, Austria
  3. 3Laboratory of Microbiology Doz. J. Möst, A-6020 Innsbruck, Austria
  4. 4Institute of Pathology, University of Basel, CH-4031 Switzerland
  5. 5Institute of Pathology, University of Innsbruck;

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    The incidence of systemic mycoses is increasing as a result of the escalating number of patients who are immunocompromised because of diabetes mellitus, haemodialysis, organ and bone marrow transplants, chemotherapy for cancer, and infections with human immunodeficiency virus (HIV), in addition to the broad use of antibiotics.1 If such predisposing factors for fungaemia are absent, fungal infections are rarely considered in the differential diagnosis when clinical status non-specifically worsens. The diagnosis of fungal infections is based on histology, cultural evidence, or serological tests.2 Histological proof of mycosis is regarded as very reliable, because the pathogenic agent can be unequivocally detected within the affected structures.3 Bone marrow examination might be a useful tool for the examination of cryptic infections, especially in HIV positive patients, with an overall diagnostic yield of 32% and 6% for fungal …

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